Email this article Phytochemical and biological evaluation of some Sargassum species from Persian Gulf
Abstract
Sea algae are widely consumed in the world. There are several seaweeds including brown algae which are authorized for human consumption. These plants contain important phytochemical constituents and have various potential biological activities. The present study investigated the presence of phytochemical constituents and total phenolic quantity of the seaweeds Sargassum angustifolium, Sargassum oligocystum and Sargassum boveanum. Cytotoxicity of seaweeds was tested against HT-29, HeLa and MCF-7 cell lines. Antioxidant potential of these 3 Sargassum species was also analyzed. Cytotoxicity was characterized by IC50 of human cancer cell lines using sulforhodamine assay. Antioxidant activities were evaluated using 2,2-diphenyl-1- picrylhydrazil. The analysis revealed that tannins, saponins, sterols and triterpenes were the most abundant compounds in these Sargassum species while cyanogenic and cardiac glycosides were the least ones. Sargassum angustifolium had the highest content of total phenolics (0.061 mg/g) and showed the highest antioxidant activity (IC50 = 0.231). Cytotoxic results showed that all species could inhibit cell growth effectively, especially MCF-7 cell line (IC50 = 67.3, 56.9, 60.4 for S. oligocystum, S. angustifolium and S. boveanum respectively). Considerable phytochemicals and moderate cytotoxic activity of S. angustifolium, S. oligocystum and S. boveanum make them appropriate candidate for further studies and identification of their bioactive principles.
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Dhargalkar VK, Neelam P. Seaweed: Promising plant of the Millennium. Sci Cult. 2005;71:60-66.
Pietra F. Secondary metabolites from marine microorganisms; bacteria, protozoa, algae and fungi:achievements and perspective. Nat Pro Rep. 1997;14:453-464.
Hemminga MA, Duarte CM. Seagrass ecology. New York: Cambridge University Press; 2000, pp 1-26.
Ragupathi Raja Kannan R, Arumugam R, Anantharaman P. Antibacterial potential of three seagrasses against human pathogens. Asian Pac J Trop Med. 2010;3:890–893.
Arumugam R, Ragupathi Raja Kannan R, Arivuselvan N, Anantharaman P. Antimicrobial potential of some seagrasses against phytopathogens. Seaweed Res Util. 2010;32:177–183.
Rowley DC, Hansen MST, Rhodes D, Sotriffer CA, Ni H, McCammon JA, et al. Thalassiolins A–C: New marine – Derived inhibitors of HIV cDNA integrase. Bioorg Med Chem. 2002;10:3619–3625.
Hua KF, Hsu HY, Su YC, Lin IF, Yang SS, Chen YM, et al. Study on the anti-inflammatory activity of methanol extract from seagrass Zostera japonica. J Agric Food Chem. 2004;54:306–311.
Gokce G, Haznedaroglu MZ. Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract. J Ethnopharmacol. 2008;115:122–130.
Athiperumalsamy T, Devi Rajeswari V, Hastha Poorna S, Kumar V, Louis Jesudass L. Antioxidant activity of seagrasses and seaweeds. Bot Mar. 2010;53:251–257.
Numata A, Kanbara S, Takahashi C, Fujiki R, Yoneda M, Fujita E, et al. Cytotoxic activity of marine algae and a cytotoxic principle of the brown alga Sargassum tortile. Chem Pharm Bull (Tokyo). 1991;39:2129–2131.
Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H. Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res. 1993;13:2045–2052.
Cho SH, Kang SE, Cho JY, Kim AR, Park SM, Hong YK, et al. The antioxidant properties of brown seaweed (Sargassum siliquastrum) extracts. J Med Food. 2010;10:479-485.
Ghannadi A. Plubrukarn A, Zandi K, Sartavi K, Yegdaneh A. Screening for antimalarial and acetylcholinesterase inhibitory activities of some Iranian seaweeds. Res Pharm Sci. 2013;8:113-118.
Vinod BS, Maliekal TT, Anto RJ. Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance. Antioxid Redox Signal. 2013;18:1307-1348.
Sohrabipour J, Rabiei R. The checklist of green algae of the Iranian coastal lines of the Persian Gulf and Gulf of Oman. Iran Journ Bot. 2007;13:146-149.
Yegdaneh A, Putchakan S, Yueyongsawad S, Ghannadi A, Plubrukarn A. 3-Oxoabolene and 1- oxocurcuphenol, Aromatic Bisabolanes from the Sponge Myrmekioderma sp. Nat Pro Com. 2013;8:1355-1357.
Kamba AS, Hassan LG. Phytochemical screening and antimicrobial activities of Euphorbia balsamifera leaves, stems and root against some pathogenic microorganisms. Afr J Pharm Pharmacol. 2010;4:645-652.
Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. Afr J Biotech. 2006;5:1142-1145.
Geran RI, Greenberg NH, Macdonald MM, Shumacher AM, Abbott BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemoth Rep1972;3:1-103.
Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia terapotensis. J Nat Pro. 2001;64:892–895.
Burtin P. Nutritional value of seaweeds. Electron J Environ Agric Food Chem. 2003;2:498-503.
Campanella L, Martini E, Tomassetti M. Antioxidant capacity of the algae using a biosensor method. Talanta. 2005;66:902-911.
Athukorala Y, Kim K, Jeon Y. Antiproliteractive and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol. 2006;44:1065-1074.
Yamamoto I, Takahashi M, Tamura E, Maruyama H, Mori H. Antitumor activity of edible marine algae: Effect of crude fucoidan fractions prepared from edible brown seaweeds against L-1210 leukemia. Hydrobiologia. 1984;116:145-148.
Kim JA, Karadeniz F, Ahn BN, Kwon MS, Mun OJ, Bae MJ, et al. Bioactive quinone derivatives from the marine brown alga Sargassum thunbergii induce anti-adipogenic and pro-osteoblastogenic activities. J Sci Food Agric. 2015;10:48-54.
Lee JI, Seo Y. Chromanols from Sargassum siliquastrum and their antioxidant activity in HT 1080 cells. Chem Pharm Bull (Tokyo). 2011;59:757-761.
Costa LS, Fidelis GP, Cordeiro SL, Oliveira RM, Sabry DA, Câmara RB, Nobre LT, Costa MS, et al. Biological activities of sulfated polysaccharides from tropical seaweeds. Biomed Pharmacother. 2010;64:21-28.
Besednova NN, Zaporozhets TS, Kuznetsova TA, Kryzhanovskiĭ SP, Kovalev NN, Zviagintseva TN. Hepatoprotective effects of extracts and polysaccharides from seaweed. Antibiot Khimioter. 2014;59:30-37.
Sadati N, Khanavi M, Mahrokh A, Nabavi SMB, Sohrabipour J, Hadjiakhoondi A. Comparison of antioxidant activity and total phenolic contents of some Persian Gulf Marine Algae. J Med Plants. 2011;10:72-79.
Targete NM, Coen LD, Boettcher AA, Tanner ChE. Biogeographic comparisons of marine algal polyphenolics: evidence against a latitudinal trend. Oceologia. 1992;89:464-470.
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