Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes

M Vosooghi, S Rajabalian, M Sorkhi, M Badinloo, M Nakhjiri, AS Negahbani, A Asadipour, M Mahdavi, A Shafiee, A Foroumadi

Abstract


A series of 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes was synthesized by condensation of 3-(dimethylamino)phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass and 1H NMR). The cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by MTT assay. Several compounds showed significant cytotoxic activity.


Keywords


Synthesis; Cytotoxic Activity; 4H-chromenes

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