Email this article The effects of hydroalcoholic extract of Allium elburzense Wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats
Abstract
Recent evidences have suggested the beneficial cardiovascular effects of some plants belonging to the genus Allium. The present study is an attempt to investigate the effects of hydroalcoholic extract of Allium elburzense bulb on dexamethasone-induced dyslipidemia in rats. Total phenolic content of A. elburzense bulb hydroalcoholic extract was determined using Folin-Ciocalteu method. Thirty-six male Wistar albino rats in 6 groups were studied. Group 1 (dyslipidemic control) received dexamethasone (10 mg/kg/day, s.c.) for 7 days, groups 2-4 (treated) received dexamethasone and simultaneously treated orally with 100, 200, or 400 mg/kg of A. elburzense extract, group 5 (normal control) received a single daily injection of normal saline (1 mL/kg, s.c.) and the vehicle orally, and group 6 (reference) received dexamethasone and atorvastatin (40 mg/kg) orally. At the end of experiment, blood glucose, lipid profile, and malondialdehyde (MDA) levels were assessed in serum samples. Livers were processed for histopathological examination. Total phenolic content of A. elburzense extract was estimated to be 33.52 ± 1.3% mg gallic acid equivalent/g of the dried plant extract. The plant extract significantly reduced serum blood glucose, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and MDA levels and increased the high density lipoprotein-cholesterol level and also improved liver steatosis compared to the dyslipidemic control group. These results suggest the hydroalcoholic extract of A. elburzense bulb has anti-dyslipidemic, anti-hyperglycemic, and antioxidant effects on rats receiving high doses of dexamethasone.
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Shattat GF. A review article on hyperlipidemia: types, treatments and new drug targets. Biomed Pharmacol J. 2014;7(2):399-409.
Howard-Alpe GM, Sear JW, Foex P. Methods of detecting atherosclerosis in non-cardiac surgical patients; the role of biochemical markers. Br J Anaesth. 2006;97(6):758-769.
Navab M, Ananthramaiah GM, Reddy ST, Van Lenten BJ, Ansell BJ, Fonarow GC, et al. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res. 2004;45(9):993-1007.
Ismail TA, Soliman MM, Nassan MA, Mohamed DI. Antihypercholesterolemic effects of mushroom, chrysin, curcumin and omega-3 in experimental hypercholesterolemic rats. J Food Nutr Res. 2015;3(2):77-87.
Ha AW, Ying T, Kim WK. The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet. Nutr Res Pract. 2015;9(1):30-36.
Neshati F, Fritsch RM. Seed characters and testa sculptures of some Iranian Allium L. species (Alliaceae). Feddes Repert. 2009;120(5-6):322-332.
Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J Nutr. 2006;136 (3 Suppl):736S-740S.
Zolfaghari B, Shokoohinia Y, Ramezanlou P, Sadeghi A, Mahmoudzadeh M, Minaiyan M. Effects of methanolic and butanolic fractions of Allium elburzense Wendelbo bulbs on blood glucose level of normal and STZ-induced diabetic rats. Res Pharm Sci. 2012;7(4):201-207.
Safaeian L, Zolfaghari B, Aghaye-Ghazvini M, Behnampour M. Evaluation of fibrinolytic and antioxidant effects of Allium elburzense bulb extracts. Avicenna J Phytomed. 2017;7(3):223-231.
Barile E, Capasso R, Izzo AA, Lanzotti V, Sajjadi SE, Zolfaghari B. Structure-activity relationships for saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activity. Planta Med. 2005;71(11):1010-1018.
Safaeian L, Ghasemi-Dehkordi N, Javanmard ShH, Namvar H. Antihypertensive and antioxidant effects of a hydroalcoholic extract obtained from aerial parts of Otostegia persica (Burm.) Boiss. Res Pharm Sci. 2015;10(3):192-199.
Kumar VR, Inamdar MN, Nayeemunnisa, Viswanatha GL. Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity. Asian Pac J Trop Med. 2011;4(8):658-660.
Momi S, Impagnatiello F, Guzzetta M, Caracchini R, Guglielmini G, Olivieri R, et al. NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties. Eur J Pharmacol. 2007;570(1-3):115-124.
Pragda SS, Kuppast IJ, Mankani KL, Ramesh L. Evaluation of antihyperlipidemic activity of leaves of Portulaca oleracea Linn against dexamethasone induced hyperlipidemia in rats. Int J Pharm Pharm Sci. 2012;4(4):279-283.
Wang M. The role of glucocorticoid action in the pathophysiology of the metabolic syndrome. Nutr Metab (Lond). 2005;2:3. Doi: 10.1186/1743-7075-2-3.
Dourakis SP, Sevastianos VA, Kaliopi P. Acute severe steatohepatitis related to prednisolone therapy. Am J Gastroenterol. 2002;97:1074-1075.
Geer EB, Islam J, Buettner C. Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinol Metab Clin North Am. 2014;43(1):75-102.
Safaeian L, Hajhashemi V, Haghjoo Javanmard S, Sanaye Naderi H. The effect of protocatechuic acid on blood pressure and oxidative stress in glucocorticoid-induced hypertension in rat. Iran J Pharm Res. 2016;15(Suppl):83-91.
Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J Nutr. 2006;136(3 Suppl):736S-740S.
Safaeian L, Ghannadi A, Javanmard SH, Vahidian MH. The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in dexamethasone-induced hypertensive rats. Res Pharm Sci. 2015;10(4):326-334.
Al-Numair KS. Hypocholesteremic and antioxidant effects of garlic (Allium sativum L.) extract in rats fed high cholesterol diet. Pak J Nutr. 2009;8(2): 161-166.
Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014;4(1):1-14.
Vidyavati HG. Manjunatha H. Hemavathy J. Srinivasan K. Hypolipidemic and antioxidant efficacy of dehydrated onion in experimental rats. J Food Sci Technol. 2010;47(1):55-60.
Sobenin IA, Pryanishnikov VV, Kunnova LM, Rabinovich YA, Martirosyan DM, Orekhov AN. The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease. Lipids Health Dis. 2010;9:119. Doi: 10.1186/1476-511X-9-119.
Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-299.
Lin YP, Lin LY, Yeh HY, Chuang CH, Tseng SW, Yen YH. Antihyperlipidemic activity of Allium chinense bulbs. J Food Drug Anal. 2016;24(3):516-526.
Corzo-Martínez M, Corzo N, Villamiel M. Biological properties of onions and garlic. Trends Food Sci Technol. 2007;18(12):609-625.
Aizikov MI, Kravets SD, Prokhorova IR, Kurmukov AG. Structure and hypolipidemic activity of alloside B extracted from anzur onions. Pharm Chem J. 1995;29(8):547-549.
Barile E, Zolfaghari B, Sajjadi SE, Lanzotti V. Saponins of Allium elburzense. J Nat Prod. 2004;67(12):2037-2042.
Matsuura H. Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr. 2001;131(3s):1000S–1005S.
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