Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators

M Mohammadpour, A Sadeghi, A Fassihi, L Saghaei, A Movahedian, M Rostami

Abstract


A series of ortho-hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. N1-Hhydroxypyridinones Va, Vb, and Ve were the best radical scavengers in DPPH free radical scavenging assay. Compound Vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. All of the synthesized compounds had very close chelating ability, compounds containing N1-CH3 hydroxypyridinone ring were stronger chelating agents.


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Creative Commons LicenseThis work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.