Dill extract attenuates liver fibrosis and steatohepatitis in obese rats via modulating TGF-β1 signaling and collagen accumulation

Azza El-Wakf, Mamdouh El-Sawi, Talal Obaid, Rehab Elmougy

Abstract


Background and purpose: Dill (Anethum graveolens) is an herbal plant from the Apiaceae family often used as an effective remedy for several ailments. This study aimed to investigate the potential protective effect of dill against the development of non-alcoholic fatty liver disease in obese rats.

Experimental approach: For 12 weeks, rats were fed a high-fat diet (HFD) to induce obesity. In the treatment group, the extract of dill leaves (100 mg/kg) was administered by gavage. Then, blood and liver samples were harvested for further investigations.

Findings/Results: Feeding HFD caused increased body mass index, abdominal circumference,                           adiposity index, weight gain, serum glucose, lipids, insulin, leptin, and insulin resistance. HFD-fed                                rats also showed increased hepatic triglycerides, fatty acid synthase, cytochrome P2E1, hydrogen                        peroxide, malondialdehyde, serum marker enzymes (AST, ALT, ALP, and GGT), and liver weight,                               with decreased antioxidants including superoxide dismutase, catalase, and glutathione. Besides, a                     significant elevation of hepatic interleukins 1β and 6, tumor necrosis factor-α, nuclear                                                        factor-kappa B, Kupfer cell markers (CD68 and CD163), fibronectin, and collagen type 1,                                                     along with an increase of transforming growth factor-β1 expression, was observed. Histological                             changes presented by hepatocytes, including ballooning, inflammatory cell aggregation, and deposition                          of collagen fibers, have also been detected. Co-administration of dill with HFD succeeded in reducing                    weight gain, hepatic triglyceride accumulation, oxidative reactions, inflammation, fibrosis, and liver                       structural injury.

Conclusion and implications: Dill extract could be approved as a promising therapeutic approach with multiple benefits for the management of obesity and associated steatohepatitis.

 

 


Keywords


Dill leaf extract; Fibrosis; Insulin resistance; Non-alcoholic fatty liver disease; Obesity; TGF-β1.

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