Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives

F Hassanzadeh, M Rahmani Khajouei, G H Hakimelahi, E Jafari, G A Khodarahmi


Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, 1HNMR and Mass spectra.

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