Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

Elham Jafari, Marzieh Rahmani Khajouei, Farshid Hassanzadeh, Gholam Hossein Hakimelahi, Ghadam Ali Khodarahmi

Abstract


The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.


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